Haplotype Reconstruction for Diploid Populations
نویسندگان
چکیده
منابع مشابه
Haplotype reconstruction for diploid populations.
The inference of haplotype pairs directly from unphased genotype data is a key step in the analysis of genetic variation in relation to disease and pharmacogenetically relevant traits. Most popular methods such as Phase and PL do require either the coalescence assumption or the assumption of linkage between the single-nucleotide polymorphisms (SNPs). We have now developed novel approaches that ...
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Malaria is an infectious disease that is caused by a group of parasites of the genus Plasmodium. Characterizing the association between polymorphisms in the parasite genome and measured traits in an infected human host may provide insight into disease aetiology and ultimately inform new strategies for improved treatment and prevention. This, however, presents an analytic challenge since individ...
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We examine the power of different exact tests of differentiation for diploid populations. Since there is not necessarily random mating within populations, the appropriate hypothesis to construct exact tests is that of independent sampling of genotypes. There are two categories of tests, FST-estimator tests and goodness of fit tests. In this latter category, we distinguish "allelic statistics", ...
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We give a new algorithm for the genotype phasing problem. Our solution is based on a hidden Markov model for haplotypes. The model has a uniform structure, unlike most solutions proposed so far that model recombinations using haplotype blocks. In our model, the haplotypes can be seen as a result of iterated recombinations applied on a few founder haplotypes. We find maximum likelihood model of ...
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Mutational meltdown, in which demographic and genetic processes mutually reinforce one another to accelerate the extinction of small populations, has been poorly quantified despite its potential importance in conservation biology. Here we present a model-based framework to study and quantify the mutational meltdown in a finite diploid population that is evolving continuously in time and subject...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2005
ISSN: 0001-5652,1423-0062
DOI: 10.1159/000085938